Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface.
نویسندگان
چکیده
Binding of exogenous [35S]sulphate-labelled cartilage proteoglycans to cells was studied with suspension cultures of calf articular-cartilage chondrocytes. Proteoglycans interact with hyaluronic acid at the cell surface via their hyaluronic acid-binding region. The binding is time-dependent and saturable, but does not appear to be freely reversible. The bound 35S-labelled proteoglycans are located at the cell surface, and only small proportions of the proteoglycans are internalized.
منابع مشابه
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عنوان ژورنال:
- The Biochemical journal
دوره 214 3 شماره
صفحات -
تاریخ انتشار 1983